Topoisomerase II inhibitors, like mitoxantrone, have been affiliated with the development of secondary acute myeloid leukemia and myelosuppression.??? ???? ?? ????? ????????? ?? ????? ??? ??????? ????? ??? ??????.Mutagenesis Mitoxantrone was clastogenic while in the in vivo rat bone marrow assay. Mitoxantrone was also clastogenic in two in vitro as